Daniela B Fenker, Mircea A Schoenfeld, Michael R Waldmann, Hartmut Schuetze, Hans-Jochen Heinze, and Emrah Duezel (2010)

``Virus and Epidemic'': Causal Knowledge Activates Prediction Error Circuitry

Journal of Cognitive Neuroscience, 22(10):2251-2163.

Knowledge about cause and effect relationships (e.g., virus- epidemic) is essential for predicting changes in the environment and for anticipating the consequences of events and one's own actions. Although there is evidence that predictions and learning from prediction errors are instrumental in acquiring causal knowledge, it is unclear whether prediction error circuitry remains involved in the mental representation and evaluation of causal knowledge already stored in semantic memory. In an fMRI study, participants assessed whether pairs of words were causally related (e.g., virus-epidemic) or noncausally associated (e.g., emerald-ring). In a second fMRI study, a task cue prompted the participants to evaluate either the causal or the noncausal associative relationship between pairs of words. Causally related pairs elicited higher activity in OFC, amygdala, striatum, and substantia nigra/ventral tegmental area than noncausally associated pairs. These regions were alsomore activated by the causal than by the associative task cue. This network overlaps with the mesolimbic and mesocortical dopaminergic network known to code prediction errors, suggesting that prediction error processing might participate in assessments of causality even under conditions when it is not explicitly required to make predictions. [ABSTRACT FROM AUTHOR]

Accession Number: 51472623; Source Information: Oct2010, Vol. 22 Issue 10, p2251; Subject Term: PREDICTION (Logic); Subject Term: VOCABULARY; Subject Term: SUBSTANTIA nigra; Subject Term: AMYGDALOID body; Subject Term: MAGNETIC resonance imaging; Subject Term: CAUSATION (Philosophy); Subject Term: ; Number of Pages: 13p; ; Illustrations: 2 Color Photographs, 1 Diagram, 2 Charts, 1 Graph; ; Document Type: Article;

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