Geänderte Inhalte

Objective: To investigate whether and to what extent mortality is predictable from facial photographs of older people. Methods: High-quality facial photographs of 292 members of the Lothian Birth Cohort 1921, taken at the age of about 83 years, were rated in terms of apparent age, health, attractiveness, facial symmetry, intelligence, and well-being by 12 young-adult raters. Cox proportional hazards regression was used to study associations between these ratings and mortality during a 7-year follow-up period. Results: All ratings had adequate reliability. Concurrent validity was found for facial symmetry and intelligence (as determined by correlations with actual measures of fluctuating asymmetry in the faces and Raven Standard Progressive Matrices score, respectively), but not for the other traits. Age as rated from facial photographs, adjusted for sex and chronological age, was a significant predictor of mortality (hazard ratio = 1.36, 95\% confidence interval = 1.12-1.65) and remained significant even after controlling for concurrent, objectively measured health and cognitive ability, and the other ratings. Health as rated from facial photographs, adjusted for sex and chronological age, significantly predicted mortality (hazard ratio = 0.81, 95\% confidence interval = 0.67-0.99) but not after adjusting for rated age or objectively measured health and cognition. Rated attractiveness, symmetry, intelligence, and well-being were not significantly associated with mortality risk. Conclusions: Rated age of the face is a significant predictor of mortality risk among older people, with predictive value over and above that of objective or rated health status and cognitive ability.

The paper by Cramer and colleagues illustrates how a network approach can model personality systems without positing causal latent factors such as the Big Five. We applaud this effort but argue that nodes should be distinguished on more than quantitative grounds (e.g. displayed centrality or connectivity). To realistically model the affects, cognitions and behaviours that constitute real personalities, organizing constructs such as needs and comparators seems necessary. Incorporating them requires greater consideration of functionalist personality theories that link together environmental features and adaptive behaviour in meaningful and stable ways. Copyright (c) 2012 John Wiley & Sons, Ltd.

A genome-wide search for genetic variants influencing the brain's white matter integrity in old age was conducted in the Lothian Birth Cohort 1936 (LBC1936). At similar to 73 years of age, members of the LBC1936 underwent diffusion MRI, from which 12 white matter tracts were segmented using quantitative tractography, and tract-averaged water diffusion parameters were determined (n = 668). A global measure of white matter tract integrity, g(FA), derived from principal components analysis of tract-averaged fractional anisotropy measurements, accounted for 38.6\% of the individual differences across the 12 white matter tracts. A genome-wide search was performed with g(FA) on 535 individuals with 542,050 single nucleotide polymorphisms (SNPs). No single SNP association was genome-wide significant (all p > 5 x 10(-8)). There was genome-wide suggestive evidence for two SNPs, one in ADAMTS18 (p = 1.65 x 10(-6)), which is related to tumor suppression and hemostasis, and another in LOC388630 (p = 5.08 x 10(-6)), which is of unknown function. Although no gene passed correction for multiple comparisons in single gene-based testing, biological pathways analysis suggested evidence for an over-representation of neuronal transmission and cell adhesion pathways relating to g(FA). (C) 2012 Elsevier Inc. All rights reserved.

The ability to judge the romantic interest between others is an important aspect of mate choice for species living in social groups. Research has previously shown that humans can do this quickly observers watching short clips of speed-dating videos can accurately predict the outcomes. Here we extend this work to show that observers from widely varying cultures can judge these same videos with roughly equal accuracy. Participants in the USA, China, and Germany perform similarly not only overall but also at the level of judging individual speed-daters: Some daters are easy to read by observers from all cultures, while others are consistently difficult. These cross-cultural performance similarities provide evidence for an adaptive mechanism useful for mate choice that could be resilient to cultural differences. (C) 2012 Elsevier Inc. All rights reserved.

General intelligence is a robust predictor of important life outcomes, including educational and occupational attainment, successfully managing everyday life situations, good health and longevity. Some neuronal correlates of intelligence have been discovered, mainly indicating that larger cortices in widespread parieto-frontal brain networks and efficient neuronal information processing support higher intelligence. However, there is a lack of established associations between general intelligence and any basic structural brain parameters that have a clear functional meaning. Here, we provide evidence that lower brain-wide white matter tract integrity exerts a substantial negative effect on general intelligence through reduced information-processing speed. Structural brain magnetic resonance imaging scans were acquired from 420 older adults in their early 70s. Using quantitative tractography, we measured fractional anisotropy and two white matter integrity biomarkers that are novel to the study of intelligence: longitudinal relaxation time (T1) and magnetisation transfer ratio. Substantial correlations among 12 major white matter tracts studied allowed the extraction of three general factors of biomarker-specific brain-wide white matter tract integrity. Each was independently associated with general intelligence, together explaining 10\% of the variance, and their effect was completely mediated by information-processing speed. Unlike most previously established neurostructural correlates of intelligence, these findings suggest a functionally plausible model of intelligence, where structurally intact axonal fibres across the brain provide the neuroanatomical infrastructure for fast information processing within widespread brain networks, supporting general intelligence.

As yet there are no firm associations between general intelligence differences and basic structural brain imaging parameters that have a clear functional meaning. Brain magnetic resonance imaging scans of 420 healthy older adults from the Lothian Birth Cohort of 1936 were analysed.

Personality traits are basic dimensions of behavioral variation, and twin, family, and adoption studies show that around 30\% of the between-individual variation is due to genetic variation. There is rapidly growing interest in understanding the evolutionary basis of this genetic variation. Several evolutionary mechanisms could explain how genetic variation is maintained in traits, and each of these makes predictions in terms of the relative contribution of rare and common genetic variants to personality variation, the magnitude of nonadditive genetic influences, and whether personality is affected by inbreeding. Using genome-wide single nucleotide polymorphism (SNP) data from > 8000 individuals, we estimated that little variation in the Cloninger personality dimensions (7.2\% on average) is due to the combined effect of common, additive genetic variants across the genome, suggesting that most heritable variation in personality is due to rare variant effects and/or a combination of dominance and epistasis. Furthermore, higher levels of inbreeding were associated with less socially desirable personality trait levels in three of the four personality dimensions. These findings are consistent with genetic variation in personality traits having been maintained by mutationselection balance.

The present cross-sectional study investigated age and gender differences in motivational manifestations of the Big Five in a large German-speaking Internet sample (N = 19,022). Participants ranging in age from 16 to 60 years completed the Five Individual Reaction Norms Inventory (FIRNI; Denissen & Penke, 2008a), and two traditional Big Five measures. Age differences were found suggesting that mean levels of neuroticism and extraversion are negatively associated with age, whereas agreeableness and conscientiousness are positively associated. Openness to experience demonstrated a curvilinear association with age, with the highest mean levels in midlife. Gender differences were found suggesting that women, on average, have higher levels of neuroticism, extraversion, and agreeableness, while men are more open to experience. Neither the main effect of gender nor Age X Gender interactions were significant in the case of conscientiousness. In comparison to the 2 traditional Big Five measures, age differences in the motivational manifestations of the Big Five as assessed by the FIRNI were more pronounced, which might be explained by the greater developmental plasticity of flexible motivational processes or the intraindividual phrasing of the items of the FIRNI, compared to the kinds of behavioral descriptions that are emphasized in traditional Big Five items. The further study of such motivational processes might contribute to a better understanding of personality development.

The association of socioeconomic status (SES) with a range of lifecourse outcomes is robust, but the causes of these associations are not well understood. Research on the developmental origins of health and disease has led to the hypothesis that early developmental disturbance might permanently affect the lifecourse, accounting for some of the burden of chronic diseases such as coronary heart disease. Here we assessed developmental disturbance using bodily and facial symmetry and examined its association with socioeconomic status (SES) in childhood, and attained status at midlife. Symmetry was measured at ages 83 (facial symmetry) and 87 (bodily symmetry) in a sample of 292 individuals from the Lothian Birth Cohort 1921 (LBC1921). Structural equation models indicated that poorer SES during early development was significantly associated with lower facial symmetry (standardized path coefficient -.25, p = .03). By contrast, midlife SES was not significantly associated with symmetry. The relationship was stronger in men (-.44, p =.03) than in women (-.12, p = .37), and the effect sizes were significantly different in magnitude (p = .004). These findings suggest that SES in early life (but not later in life) is associated with developmental disturbances. Facial symmetry appears to provide an effective record of early perturbations, whereas bodily symmetry seems relatively imperturbable. As bodily and facial symmetries were sensitive to different influences, they should not be treated as interchangeable. However, markers of childhood disturbance remain many decades later, suggesting that early development may account in part for associations between SES and health through the lifecourse. Future research should clarify which elements of the environment cause these perturbations. (C) 2011 Elsevier B.V. All rights reserved.

High facial width-to-height ratio (fWHR) has been associated with a cluster of behavioural traits in men, including aggression and status-striving. This association between face structure and behaviour may be caused by testosterone. Here we investigated the relationship of both baseline and reactive testosterone levels to fWHR. In addition, we investigated the link between testosterone and three well-characterised sexually dimorphic facial metrics. Testosterone was measured in one sample of males (n = 185) before and after a speed-dating event. An additional sample provided only baseline testosterone measures (n = 92). fWHR was positively associated with testosterone reactions to potential mate exposure and marginally associated with baseline testosterone in Sample 1. We found a positive association with baseline testosterone and fWHR in Sample 2. In addition, face-width-to-lower-height ratio was positively associated with testosterone in both samples, suggesting that, in particular, facial width (scaled by two measures of facial height) is associated with testosterone. Importantly, our results also indicate that there is no association between adult testosterone and the sexual dimorphism of face shape. Thus, while our findings question the status of sexual dimorphism as a proxy measure of testosterone, they do provide evidence that testosterone is linked to fWHR and might underlie the relationship between fWHR and behaviour. (C) 2013 Elsevier Inc. All rights reserved.

Objective: The present study investigates associations between brain white matter tract integrity and cognitive abilities in community-dwelling older people (N = 655). We explored two potential confounds of white matter tract cognition associations in later life: (a) whether the associations between tracts and specific cognitive abilities are accounted for by general cognitive ability (g); and (b) how the presence of atrophy and white matter lesions affect these associations. Method: Tract integrity was determined using quantitative diffusion magnetic resonance imaging tractography (tract-averaged fractional anisotropy [FAD. Using confirmatory factor analysis, we compared first-order and bifactor models to investigate whether specific tract-ability associations were accounted for by g. Results: Significant associations were found between g and FA in bilateral anterior thalamic radiations (r range: .16-.18, p < .01), uncinate (r range: .19-.26, p < .001), arcuate fasciculi (r range: .11-.12, p < .05), and the splenium of corpus callosum (r = .14, p < .01). After controlling for g within the bifactor model, some significant specific cognitive domain associations remained. Results also suggest that the primary effects of controlling for whole brain integrity were on g associations, not specific abilities. Conclusion: Results suggest that g accounts for most of, but not all, the tract-cognition associations in the current data. When controlling for age-related overall brain structural changes, only minor attenuations of the tract-cognition associations were found, and these were primarily with g. In totality, the results highlight the importance of controlling for,g when investigating associations between specific cognitive abilities and neuropsychology variables.

Objective Although previous studies have found personality traits to be associated with reproductive behavior, it remains unclear whether there are dyadic associations between partners' personality and couples' decisional process to have children. The aim of the present study was to investigate the associations between partners' personality, parenthood expectations and intentions, and the couple's fertility outcomes one year later. Method We used dyadic longitudinal data from 2,482 couples with a mean age of 32.7 years (SD=5.9) participating in the Panel Analysis of Intimate Relationships and Family Dynamics (PAIRFAM). Results Self-esteem, shyness, and aggressiveness of both partners were related to one's own and one's partner's expectations about parenthood. These expectations were associated with one's own and one's partner's intentions to become a parent, which in turn predicted the couple's actual fertility outcomes. Personality traits of both partners were directly associated with the fertility outcome, with self-esteem of both partners and male aggressiveness predicting the couple's decision to have their first child. The effect of self-esteem on the decision to become a parent was mediated by the partner's intention. Conclusions In sum, our findings stress the importance of psychological factors in fertility outcomes and emphasize the role of dyadic processes.

Cerebral white matter hyperintensities (WMH) reflect accumulating white matter damage with aging and impair cognition. The role of childhood intelligence is rarely considered in associations between cognitive impairment and WMH. We studied community-dwelling older people all born in 1936, in whom IQ had been assessed at age 11 years. We assessed medical histories, current cognitive ability and quantified WMH on MR imaging. Among 634 participants, mean age 72.7 (SD 0.7), age 11 IQ was the strongest predictor of late life cognitive ability. After accounting for age 11 IQ, greater WMH load was significantly associated with lower late life general cognitive ability (beta = -0.14, p < 0.01) and processing speed (beta = -0.19, p < 0.001). WMH were also associated independently with lower age 11 IQ (beta = -0.08, p < 0.05) and hypertension. In conclusion, having more WMH is significantly associated with lower cognitive ability, after accounting for prior ability, age 11IQ. Early-life IQ also influenced WMH in later life. Determining how lower IQ in youth leads to increasing brain damage with aging is important for future successful cognitive aging. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.

Brain tissue deterioration is a significant contributor to lower cognitive ability in later life; however, few studies have appropriate data to establish how much influence prior brain volume and prior cognitive performance have on this association. We investigated the associations between structural brain imaging biomarkers, including an estimate of maximal brain volume, and detailed measures of cognitive ability at age 73 years in a large (N = 620), generally healthy, community-dwelling population. Cognitive ability data were available from age 11 years. We found positive associations (r) between general cognitive ability and estimated brain volume in youth (male, 0.28; females, 0.12), and in measured brain volume in later life (males, 0.27; females, 0.26). Our findings show that cognitive ability in youth is a strong predictor of estimated prior and measured current brain volume in old age but that these effects were the same for both white and gray matter. As 1 of the largest studies of associations between brain volume and cognitive ability with normal aging, this work contributes to the wider understanding of how some early-life factors influence cognitive aging. (C) 2013 Elsevier Inc. All rights reserved.

In this article, we present an integrative perspective on temperament and personality development. Personality and temperament are conceptualized as regulatory systems that start as physiological reactivity to environmental features early in life, but are increasingly supplemented by regulation efforts oriented toward reference values such as personal goals and social norms. These reference values change during development as society expects increasingly mature behaviors, but it takes regulatory resources and incremental practice before people can conform to these higher standards. Consistent with this view, a meta-analysis of mean-level development of personality traits in adolescence revealed a decrease in conscientiousness and openness during early adolescence. Negative discrepancies between reference values and actual behavior are apparently responsible for decreases in perceived maturity, but more direct evidence is needed to support this claim.

Paternal age at conception has been found to predict the number of new genetic mutations. We examined the effect of father's age at birth on offspring intelligence, head circumference and personality traits. Using the Minnesota Twin Family Study sample we tested paternal age effects while controlling for parents' trait levels measured with the same precision as offspring's. From evolutionary genetic considerations we predicted a negative effect of paternal age on offspring intelligence, but not on other traits. Controlling for parental intelligence (IQ) had the effect of turning an initially positive association non-significantly negative. We found paternal age effects on offspring IQ and Multidimensional Personality Questionnaire Absorption, but they were not robustly significant, nor replicable with additional covariates. No other noteworthy effects were found. Parents' intelligence and personality correlated with their ages at twin birth, which may have obscured a small negative effect of advanced paternal age (< 1\% of variance explained) on intelligence. We discuss future avenues for studies of paternal age effects and suggest that stronger research designs are needed to rule out confounding factors involving birth order and the Flynn effect.

Previous research has shown that men with higher facial width-to-height ratios (fWHRs) have higher testosterone and are more aggressive, more powerful, and more financially successful. We tested whether they are also more attractive to women in the ecologically valid mating context of speed dating. Men's fWHR was positively associated with their perceived dominance, likelihood of being chosen for a second date, and attractiveness to women for short-term, but not long-term, relationships. Perceived dominance (by itself and through physical attractiveness) mediated the relationship between fWHR and attractiveness to women for short-term relationships. Furthermore, men's perceptions of their own dominance showed patterns of association with mating desirability similar to those of fWHR. These results support the idea that fWHR is a physical marker of dominance. This is the first study to show that male dominance and higher fWHRs are attractive to women for short-term relationships in a controlled and interactive situation that could actually lead to mating and dating.

Hippocampal structural integrity is commonly quantified using volumetric measurements derived from brain magnetic resonance imaging (MRI). Previously reported associations with cognitive decline have not been consistent. We investigate hippocampal integrity using quantitative MRI techniques and its association with cognitive abilities in older age. Participants from the Lothian Birth Cohort 1936 underwent brain MRI at mean age 73 years. Longitudinal relaxation time (T1), magnetization transfer ratio (MTR), fractional anisotropy (FA) and mean diffusivity (MD) were measured in the hippocarnpus. General factors of fluidtype intelligence (g), cognitive processing speed (speed) and memory were obtained at age 73 years, as well as childhood IQ test results at age 11 years. Amongst 565 older adults, multivariate linear regression showed that, after correcting for ICV, gender and age 11 IQ larger left hippocampal volume was significantly associated with better memory ability (beta = .11,p = .003), but not with speed or g. Using quantitative MRI and after correcting for multiple testing, higher Ti and MD were significantly associated with lower scores of g (beta range = -.11 to -.14, p < .001), speed (beta range = -.15 to -.20, p < .001) and memory (beta range = -.10 to -.12, p < .001). Higher MTR and FA in the hippocampus were also significantly associated with higher scores of g (beta range = .17 to .18, p < .0001) and speed (beta range = .10 to .15, p < .0001), but not memory.

The influence of emotion on moral judgments has become increasingly prominent in recent years. While explicit normative measures are widely used to investigate this relationship, event-related potentials (ERPs) offer the advantage of a preconscious method to visualize the modulation of moral judgments. Based on Gray and Wegner’s (2009)  Dimensional Moral Model , the present study investigated whether the processing of neutral faces is modulated by moral context information. We hypothesized that neutral faces gain emotional valence when presented in a moral context and thus elicit ERP responses comparable to those established for the processing of emotional faces. Participants ( N = 26, 13 female) were tested with regard to their implicit (ERPs) and explicit (morality rating) responses to neutral faces, shown in either a morally positive, negative, or neutral context. Higher ERP amplitudes in early (P100, N170) and later (EPN, LPC) processing stages were expected for harmful/helpful scenarios compared to neutral scenarios. Agents and patients were expected to differ for moral compared to neutral scenarios. In the explicit ratings neutral scenarios were expected to differ from moral scenarios. In ERPs, we found indications for an early modulation of moral valence (harmful/helpful) and an interaction of agency and moral valence after 80-120 ms. Later time sequences showed no significant differences. Morally positive and negative scenarios were rated as significantly different from neutral scenarios. Overall, the results indicate that the relationship of emotion and moral judgments can be observed on a preconscious neural level at an early processing stage as well as in explicit judgments.

Human faces express emotions, informing others about their affective states. In order to measure expressions of emotion, facial Electromyography (EMG) has widely been used, requiring electrodes and technical equipment. More recently, emotion recognition software has been developed that detects emotions from video recordings of human faces. However, its validity and comparability to EMG measures is unclear. The aim of the current study was to compare the Affectiva Affdex emotion recognition software by iMotions with EMG measurements of the zygomaticus mayor and corrugator supercilii muscle, concerning its ability to identify happy, angry and neutral faces. Twenty participants imitated these facial expressions while videos and EMG were recorded. Happy and angry expressions were detected by both the software and by EMG above chance, while neutral expressions were more often falsely identified as negative by EMG compared to the software. Overall, EMG and software values correlated highly. In conclusion, Affectiva Affdex software can identify facial expressions and its results are comparable to EMG findings.